Login | Request Account (DAF staff only)

Geministatins: new depside antibiotics from the fungus Austroacremonium gemini

Share this record

Add to FacebookAdd to LinkedinAdd to XAdd to WechatAdd to Microsoft_teamsAdd to WhatsappAdd to Any

Export this record

View Altmetrics

Crombie, A., Kalaitzis, J. A., Chen, R., Vuong, D., Lacey, A. E., Lacey, E., Shivas, R. G., Tan, Y. P., Sbaraini, N., Chooi, Y.-H. and Piggott, A. M. (2024) Geministatins: new depside antibiotics from the fungus Austroacremonium gemini. The Journal of Antibiotics . ISSN 1881-1469


Article Link: https://doi.org/10.1038/s41429-024-00755-x


Two new depside antibiotics, geministatins A (1) and B (2), were isolated from the fungus Austroacremonium gemini MST-FP2131 (Sordariomycetes, Ascomycota), which was recovered from rotting wood in the wet tropics of northern Australia. The structures of the geministatins were elucidated by detailed spectroscopic analysis, chemical degradation and comparison with literature values. Chemical degradation of 1 and 2 yielded three new analogues, geministatins C–E (3–5), as well as a previously reported compound dehydromerulinic acid A (6). Compounds 1, 2 and 6 exhibited antibacterial activity against the Gram-positive bacteria Bacillus subtilis (MIC 0.2–1.6 µg mL−1) and Staphylococcus aureus (MIC 0.78–6.3 µg mL−1), including methicillin-resistant S. aureus (MRSA), while 4 exhibited antifungal activity against the yeast Saccharomyces cerevisiae (MIC 13 µg mL−1).

Item Type:Article
Corporate Creators:Department of Agriculture and Fisheries, Queensland
Business groups:Biosecurity Queensland
Keywords:Soil microbiology Structure elucidation
Subjects:Science > Biology > Biochemistry
Science > Microbiology > Microbial ecology
Agriculture > Agriculture (General) > Soils. Soil science
Live Archive:01 Jul 2024 04:54
Last Modified:01 Jul 2024 04:54

Repository Staff Only: item control page


Downloads per month over past year

View more statistics