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Geministatins: new depside antibiotics from the fungus Austroacremonium gemini

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Crombie, A., Kalaitzis, J. A., Chen, R., Vuong, D., Lacey, A. E., Lacey, E., Shivas, R. G., Tan, Y. P., Sbaraini, N., Chooi, Y.-H. and Piggott, A. M. (2024) Geministatins: new depside antibiotics from the fungus Austroacremonium gemini. The Journal of Antibiotics, 77 . pp. 639-646. ISSN 1881-1469

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Article Link: https://doi.org/10.1038/s41429-024-00755-x

Abstract

Two new depside antibiotics, geministatins A (1) and B (2), were isolated from the fungus Austroacremonium gemini MST-FP2131 (Sordariomycetes, Ascomycota), which was recovered from rotting wood in the wet tropics of northern Australia. The structures of the geministatins were elucidated by detailed spectroscopic analysis, chemical degradation and comparison with literature values. Chemical degradation of 1 and 2 yielded three new analogues, geministatins C–E (3–5), as well as a previously reported compound dehydromerulinic acid A (6). Compounds 1, 2 and 6 exhibited antibacterial activity against the Gram-positive bacteria Bacillus subtilis (MIC 0.2–1.6 µg mL−1) and Staphylococcus aureus (MIC 0.78–6.3 µg mL−1), including methicillin-resistant S. aureus (MRSA), while 4 exhibited antifungal activity against the yeast Saccharomyces cerevisiae (MIC 13 µg mL−1).

Item Type:Article
Corporate Creators:Department of Agriculture and Fisheries, Queensland
Business groups:Biosecurity Queensland
Keywords:Soil microbiology Structure elucidation
Subjects:Science > Biology > Biochemistry
Science > Microbiology > Microbial ecology
Agriculture > Agriculture (General) > Soils. Soil science
Live Archive:01 Jul 2024 04:54
Last Modified:04 Oct 2024 00:51

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