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The nootropic drug vinpocetine modulates different types of potassium currents in molluscan neurons

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Solntseva, E.I., Bukanova, J.V. and Skrebitsky, V.G. (2001) The nootropic drug vinpocetine modulates different types of potassium currents in molluscan neurons. Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology, 128 (2). pp. 275-280. ISSN 1878-1659

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Article Link: https://doi.org/10.1016/S1532-0456(01)00202-2


Three types of high-threshold K+ currents were recorded in isolated neurons of the snail Helix pomatia using a two-microelectrode voltage clamp technique: transient K+ current (IA), delayed rectifier (IKD) and Ca2+-dependent K+ current (IK(Ca)). Vinpocetine (1–100 μM) applied to the bath affected different types of K+ current in different ways: IA was increased (35±14%), IKD was moderately inhibited (20±9%) and IK(Ca) was strongly suppressed (45±15%). When IA and IK(Ca) were present in the same cell, vinpocetine exerted a dual effect on the total K+ current, depending on the amplitude of the test stimulus. In the presence of vinpocetine, the I–V curve crossed the control I–V curve. The inhibition of IK(Ca) by vinpocetine between 1 and 100 μM is unlikely to be a result of Ca2+ current (ICa) suppression, as the latter was inhibited only at vinpocetine concentrations exceeding 300 μM. Dibutyryl cyclic GMP (dbcGMP) (but not dbcAMP) mimicked the effects of vinpocetine in the majority of cells tested (coefficient of correlation r=0.60, P<0.05, n=22). The data suggest that modulation of different types of K+ current in neuronal membrane can contribute, at least partially, to the nootropic effect of vinpocetine through the regulation of intracellular Ca2+ concentration.

Item Type:Article
Subjects:Science > Biology > Biochemistry
Live Archive:09 Jan 2024 05:14
Last Modified:09 Jan 2024 05:14

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