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Haemolytic fungi isolated from sago starch in papua New Guinea

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Greenhill, A.R., Blaney, B.J., Shipton, W.A., Pue, A., Fletcher, M.T. and Warner, J.M. (2010) Haemolytic fungi isolated from sago starch in papua New Guinea. Mycopathologia, 169 (2). pp. 107-115. ISSN 0301486X (ISSN)

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Article Link(s): https://doi.org/10.1007/s11046-009-9235-3

Abstract

Sago haemolytic disease (SHD) is a rare but often fatal illness linked to consumption of stale sago starch in Papua New Guinea. Although the aetiology of SHD remains unknown, mycotoxins are suspected. This study investigated whether fungi isolated from Papua New Guinean sago starch were haemolytic. Filamentous fungi and yeasts from sago starch were grown on sheep blood agar and some on human blood agar. Clear haemolytic activity was demonstrated by 55% of filamentous fungal isolates, but not by yeasts. A semi-quantitative bioassay was developed involving incubation of human erythrocytes with fungal extracts. Extracts of cultures of Penicillium, Aspergillus and Fusarium all caused rapid haemolysis in the bioassay. Partial fractionation of extracts suggested that both polar and non-polar haemolytic components had haemolytic activity in vitro. Further work is warranted to identify these metabolites and determine if they play a role in SHD. © Springer Science+Business Media B.V. 2009.

Item Type:Article
Business groups:Biosecurity Queensland
Keywords:Aspergillus Fusarium Haemolysis Mycotoxin Penicillium Sago starch Trichoderma starch animal Arecaceae article chemistry culture medium drug effect erythrocyte fungus growth, development and aging hemolysis human isolation and purification microbiology Papua New Guinea pathogenicity sheep Animals Culture Media Erythrocytes Fungi Humans Mycotoxins Ovis aries
Subjects:Science > Botany > Cryptogams
Agriculture > Agriculture (General) > Agricultural chemistry. Agricultural chemicals
Plant pests and diseases
Plant pests and diseases > Plant pathology
Deposited On:17 Jan 2023 05:23
Last Modified:17 Jan 2023 05:23

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