Login | Request Account (DAF staff only)

Pestalactams A-C: Novel caprolactams from the endophytic fungus Pestalotiopsis sp

Share this record

Add to FacebookAdd to LinkedinAdd to XAdd to WechatAdd to Microsoft_teamsAdd to WhatsappAdd to Any

Export this record

View Altmetrics

Davis, R. A., Carroll, A. R., Andrews, K. T., Boyle, G. M., Tran, T. L., Healy, P. C., Kalaitzis, J. A. and Shivas, R. G. (2010) Pestalactams A-C: Novel caprolactams from the endophytic fungus Pestalotiopsis sp. Organic and Biomolecular Chemistry, 8 (8). pp. 1785-1790. ISSN 14770520 (ISSN)

Full text not currently attached. Access may be available via the Publisher's website or OpenAccess link.

Article Link: https://doi.org/10.1039/b924169h


Chemical investigations of a fermentation culture from the endophytic fungus Pestalotiopsis sp. yielded three novel caprolactams, pestalactams A-C (1-3). The structures of 1-3 were determined by analysis of 1D and 2D-NMR, UV, IR, and MS data. The structure of pestalactam A was confirmed following single crystal X-ray diffraction analysis. Pestalactams A-C are the first C-7 alkylated caprolactam natural products to be reported. Pestalactams A (1) and B (2) were tested against two different strains of the malaria parasite Plasmodium falciparum (3D7 and Dd2), and the mammalian cell lines, MCF-7 and NFF, and showed modest in vitro activity in all assays. © 2010 The Royal Society of Chemistry.

Item Type:Article
Business groups:Biosecurity Queensland
Keywords:Endophytic fungi Fermentation culture In-vitro Malaria parasite Mammalian cell lines Natural products Plasmodium falciparum Single crystal X-ray diffraction analysis Animal cell culture Cell culture Crystal structure Fungi Mammals Single crystals X ray diffraction X ray diffraction analysis antimalarial agent caprolactam animal article Ascomycetes cell line cell proliferation chemical structure chemistry drug effect fermentation human isolation and purification metabolism tumor cell line Animals Antimalarials Ascomycota Cell Line, Tumor Humans Models, Molecular Mammalia Pestalotiopsis sp.
Subjects:Science > Botany > Cryptogams
Agriculture > Agriculture (General) > Agricultural chemistry. Agricultural chemicals
Live Archive:17 Jan 2023 04:02
Last Modified:17 Jan 2023 04:02

Repository Staff Only: item control page