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Rhabdovirus accessory genes

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Walker, P. J., Dietzgen, R. G., Joubert, D. A. and Blasdell, K. R. (2011) Rhabdovirus accessory genes. Virus Research, 162 (1-2). pp. 110-125.

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Article Link: http://doi.org/10.1016/j.virusres.2011.09.004


The Rhabdoviridae is one of the most ecologically diverse families of RNA viruses with members infecting a wide range of organisms including placental mammals, marsupials, birds, reptiles, fish, insects and plants. The availability of complete nucleotide sequences for an increasing number of rhabdoviruses has revealed that their ecological diversity is reflected in the diversity and complexity of their genomes. The five canonical rhabdovirus structural protein genes (N, P, M, G and L) that are shared by all rhabdoviruses are overprinted, overlapped and interspersed with a multitude of novel and diverse accessory genes. Although not essential for replication in cell culture, several of these genes have been shown to have roles associated with pathogenesis and apoptosis in animals, and cell-to-cell movement in plants. Others appear to be secreted or have the characteristics of membrane-anchored glycoproteins or viroporins. However, most encode proteins of unknown function that are unrelated to any other known proteins. Understanding the roles of these accessory genes and the strategies by which rhabdoviruses use them to engage, divert and re-direct cellular processes will not only present opportunities to develop new anti-viral therapies but may also reveal aspects of cellar function that have broader significance in biology, agriculture and medicine. © 2011.

Item Type:Article
Keywords:Accessory gene Cytorhabdovirus Ephemerovirus Insect-transmitted rhabdovirus Lyssavirus Novirhabdovirus Nucleorhabdovirus Rhabdovirus Vesiculovirus dihydrolipoamide dehydrogenase glycine dehydrogenase (decarboxylating) guanine nucleotide binding protein M protein protein C RNA polymerase STAT1 protein 3' untranslated region 5' untranslated region amino acid sequence apoptosis cell culture cell function cell motion cytoplasm enzyme activity gene duplication gene expression gene function gene location glycosylation in vitro study microbial diversity nonhuman nucleotide sequence Oncorhynchus open reading frame pathogenicity plant polyadenylation priority journal protein analysis protein degradation protein domain protein expression protein function protein localization Rabies virus review RNA sequence RNA synthesis sigma virus Sonchus tibrovirus Vesicular stomatitis virus Viral hemorrhagic septicemia virus virogenesis virus virus characterization virus gene virus immunity virus inhibition virus morphology virus replication virus strain virus transcription Animals Biological Evolution Fishes Genes, Viral Humans Insects Molecular Sequence Data Phylogeny Plants Rhabdoviridae Rhabdoviridae Infections RNA, Viral Sequence Alignment Sequence Homology, Amino Acid Transcription, Genetic Viral Proteins Animalia Aves Eutheria Hexapoda Metatheria Reptilia RNA viruses
Subjects:Science > Microbiology > Virology
Live Archive:05 Apr 2019 00:03
Last Modified:03 Sep 2021 16:45

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