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Development of effective living vaccines against bovine babesiosis - The longest field trial?

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Callow, L.L., Dalgliesh, R.J. and De Vos, A.J. (1997) Development of effective living vaccines against bovine babesiosis - The longest field trial? International Journal for Parasitology, 27 (7). pp. 747-767. ISSN 0020-7519

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Article Link: https://doi.org/10.1016/S0020-7519(97)00034-9


Between 1959 and 1996, research was performed to change a vaccine against babesiosis in Australia and to improve it as actual or threatened untoward field responses became apparent. The most significant change occurred in 1964 with the traditionally used carriers of Babesia being replaced as vaccine donors by acutely infected splenectomised calves. This ensured the infectivity of the vaccine and was fortuitously associated with a reduction in the virulence of Babesia bovis in vaccine. Since then, more than 27 million doses of highly infective vaccine have been supplied from the laboratory at Wacol near Brisbane. This vaccine reduced serious losses from babesiosis in vaccinated cattle in Australia to very low levels and has now gained acceptance worldwide. Research to ensure the continuing effectiveness of the vaccine has proved to be essential.

Item Type:Article
Keywords:Babesiosis, Babesia bovis, Babesia bigemina, tick fever, vaccine, Boophilus microplus
Subjects:Science > Microbiology > Immunology
Veterinary medicine > Veterinary parasitology
Veterinary medicine > Diseases of special classes of animals > Cattle
Live Archive:27 Mar 2024 01:38
Last Modified:27 Mar 2024 01:38

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