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Phage Biotechnology to Mitigate Antimicrobial Resistance in Agriculture

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Premaratne, A., Zhang, H., Wang, R., Chinivasagam, N. H. and Billington, C. (2021) Phage Biotechnology to Mitigate Antimicrobial Resistance in Agriculture. In: Sustainable Agriculture Reviews 49: Mitigation of Antimicrobial Resistance Vol 2. Natural and Synthetic Approaches. Springer International Publishing, Cham. ISBN 978-3-030-58259-3

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Article Link: https://doi.org/10.1007/978-3-030-58259-3_9


The prevalence of key antibiotic resistant bacteria was reported by the World Health Organization in 2014 and they found very high rates of resistance in all regions of the globe. The United States Centres for Disease Control has also estimated that 20% of the two million antibiotic resistant infections in the US are linked to agricultural use. Antibiotics provide a vital function in reducing mortality in humans and animals, so their efficacy must be protected by coordinated action across multiple sectors, including agriculture. Alongside better antibiotic stewardship, a key to achieving this goal must be the development of new antimicrobial agents. For agriculture, a renewed focus on intensification, food security and reduced food loss also provide additional pressures on controlling bacterial infections and spoilage. Here, we discuss the potential of a new class of antimicrobial agents, phages, as a replacement or supplement, to some of the conventional antibiotics currently used in agriculture. We show that phages have many of the desirable properties needed to control bacterial diseases in agriculture including efficacy, low levels of resistance, lack of cross-resistance to antibiotics, biodegradability and narrow target range.

Item Type:Book Section
Business groups:Animal Science
Keywords:Phage Biocontrol Agriculture Biotechnology Antimicrobial resistance Poultry Pigs Cattle Plant disease One health
Subjects:Science > Microbiology
Science > Microbiology > Microorganisms in the animal body
Animal culture > Cattle
Animal culture > Swine
Animal culture > Poultry
Veterinary medicine > Veterinary microbiology
Veterinary medicine > Veterinary bacteriology
Live Archive:12 Jan 2021 01:34
Last Modified:03 Sep 2021 16:46

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