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Consumption of anthocyanin-rich Queen Garnet plum juice reduces platelet activation related thrombogenesis in healthy volunteers

Santhakumar, Abishek Bommannan and Kundur, Avinash Reddy and Fanning, Kent and Netzel, Michael and Stanley, Roger and Singh, Indu (2015) Consumption of anthocyanin-rich Queen Garnet plum juice reduces platelet activation related thrombogenesis in healthy volunteers. Journal of Functional Foods, 12 . p. 11. ISSN 17564646

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Article Link(s): http://dx.doi.org/10.1016/j.jff.2014.10.026

Publisher URL: http://www.sciencedirect.com/science/article/pii/S1756464614003326

Abstract

The anti-thrombotic properties of an anthocyanin-rich Queen Garnet plum juice (QGPJ) and anthocyanin-free prune juice (PJ) were studied in this randomised, double-blind, crossover trial. Twenty-one healthy subjects (M = 10, F = 11) consumed QGPJ, PJ or placebo, 200 mL/day for 28-days followed by a 2-week wash-out period. Only QGPJ supplementation inhibited platelet aggregation induced by ADP (<5%, P = 0.02), collagen (<2.7%, P < 0.001) and arachidonic acid (<4%, P < 0.001); reduced platelet activation-dependent surface-marker P-selectin expression of activated de-granulated platelets (<17.2%, P = 0.04); prolonged activated-partial thromboplastin clotting time (>2.1 s, P = 0.03); reduced plasma-fibrinogen (<7.5%, P = 0.02) and malondialdehyde levels, a plasma biomarker of oxidative stress ( P = 0.016). PJ supplementation increased plasma hippuric acid content ( P = 0.018). QGPJ or PJ supplementation did not affect blood cell counts, lipid profile, or inflammation markers. Our findings suggest that QGPJ but not PJ has the potential to significantly attenuate thrombosis by reducing platelet activation/hyper-coagulability and oxidative stress.

Item Type:Article
Business groups:Crop and Food Science
Keywords:Anthocyanins Anti-platelet therapy Platelet activity Queen-Garnet plum Thrombosis Prunus domestica
Subjects:Plant culture > Fruit and fruit culture
Agriculture > Agriculture (General) > Agricultural chemistry. Agricultural chemicals
Deposited On:18 Mar 2015 03:37
Last Modified:18 Mar 2015 03:37

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