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Polyphenolic contents and the effects of methanol extracts from mango varieties on breast cancer cells

Hoang, Van Le Thu and Pierson, Jean-Thomas and Curry, Merril Carmel and Shaw, Paul Nicholas and Dietzgen, Ralf Georg and Gidley, Michael John and Roberts-Thomson, Sarah Jane and Monteith, Gregory Raymond (2015) Polyphenolic contents and the effects of methanol extracts from mango varieties on breast cancer cells. Food Science and Biotechnology, 24 (1). p. 265. ISSN 1226-7708

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Article Link(s): http://dx.doi.org/10.1007/s10068-015-0035-x


Bioactivities of peel and flesh extracts of 3 genetically diverse mango (Mangifera indica L.) varieties were studied. Nam Doc Mai peel extracts, containing the largest amounts of polyphenols, were associated with an effect on MCF-7 viable cell numbers with an IC50 (dose required for 50% inhibition of cell viability) of 56 μg/mL and significantly (p<0.01) induced cell death in MDA-MB-231 cells, compared with other varieties. Hydrophilic fractions of Nam Doc Mai peel extracts had the highest bioactivity values against both MCF-7 and MDA-MB-231 cells. Soluble polyphenols were present in the largest amounts in most hydrophilic fractions. The Nam Doc Mai mango variety contains high levels of fruit peel bioactivity, which appears to be related to the nature of the polyphenol composition.

Item Type:Article
Business groups:Horticulture and Forestry Science
Keywords:breast cancer mango polyphenolic viability Bioactivity Cell death Cytology Diseases Fruits Hydrophilicity Breast cancer cells Mangifera indica Methanol extract Polyphenolic content Cells
Subjects:Plant culture > Fruit and fruit culture
Agriculture > Agriculture (General) > Agricultural chemistry. Agricultural chemicals
Deposited On:18 Mar 2015 03:24
Last Modified:18 Mar 2015 03:24

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