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Radish sprouts versus broccoli sprouts: a comparison of anti-cancer potential based on glucosinolate breakdown products.

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O'Hare, T.J., Williams, D.J., Zhang, B., Wong, L.S., Jarrett, S., Pun, S., Jorgensen, W., and Imsic, M. (2009) Radish sprouts versus broccoli sprouts: a comparison of anti-cancer potential based on glucosinolate breakdown products. Acta Horticulturae . pp. 187-192. ISSN 0567-7572

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Article Link: https://doi.org/10.17660/ActaHortic.2009.841.21

Publisher URL: http://www.actahort.org/books/841/841_21.htm

Abstract

Radish sprouts and broccoli sprouts have been implicated in having a potential chemoprotective effect against certain types of cancer. Each contains a glucosinolate that can be broken down to an isothiocyanate capable of inducing chemoprotective factors known as phase 2 enzymes. In the case of broccoli, the glucosinolate, glucoraphanin, is converted to an isothiocyanate, sulforaphane, while in radish a similar glucosinolate, glucoraphenin, is broken down to form the isothiocyanate, sulforaphene. When sprouts are consumed fresh (uncooked), however, the principal degradation product of broccoli is not the isothiocyanate sulforaphane, but a nitrile, a compound with little anti-cancer potential. By contrast, radish sprouts produce largely the anti-cancer isothiocyanate, sulforaphene. The reason for this difference is likely to be due to the presence in broccoli (and absence in radish) of the enzyme cofactor, epithiospecifier protein (ESP). In vitro induction of the phase 2 enzyme, quinone reductase (QR), was significantly greater for radish sprouts than broccoli sprouts when extracts were self-hydrolysed. By contrast, boiled radish sprout extracts (deactivating ESP) to which myrosinase was subsequently added, induced similar QR activity to broccoli sprouts. The implication is that radish sprouts have potentially greater chemoprotective action against carcinogens than broccoli sprouts when hydrolysed under conditions similar to that during human consumption.

Item Type:Article
Business groups:Crop and Food Science, Horticulture and Forestry Science
Additional Information:© ISHS
Keywords:Anticarcinogenic properties; broccoli; chemical composition; glucosinolates; plant composition; plant extracts; radishes; glucoraphenin; glucoraphanin; epithiospecifier protein; sulforaphene; sulforaphane; isothiocyanate.
Subjects:Science > Science (General)
Science > Biology > Biochemistry
Plant culture > Vegetables
Live Archive:23 Jun 2010 05:15
Last Modified:01 Dec 2022 05:05

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