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Effect of parenteral antioxidants on adrenal pathobiology and leukocytes in hyperammonaemic toxaemia

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Guerrini, V. H. (1995) Effect of parenteral antioxidants on adrenal pathobiology and leukocytes in hyperammonaemic toxaemia. Free Radical Research, 22 (6). pp. 545-553. ISSN 1029-2470

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Article Link: https://doi.org/10.3109/10715769509150326


Infestation of sheep by L. cuprina larvae produces extensive skin wounds, severe dermatitis, hyperammonaemia and stress with adrenal necrosis and haemmorhage. In infested sheep, intramuscular (im) injections of Dl-Alpha tocopherol induced wool shedding and Desferrioxamine im prevented declines in white blood cells (WBC). In further trials, daily im injections of sodium ascorbate with Dl-alpha tocopherol, desferrioxamine and oral butylated-hydroxyanisole prevented adrenal damage and induced adrenocortical hypertrophy of the zona fasciculata. The treatment boosted the levels of mature and juvenile neutrophils, and blood glucose. Increases in toxic ammonia levels were correlated with increased toxic and band neutrophils, and globulin levels in treated sheep and toxic neutrophils in non-treated sheep. Decreases in serum zinc were correlated with declining lymphocytes and globulin levels. The results suggested that antioxidants protect and enhance adrenal activation in hyperammonaemic toxaemia. The changes in WBC, globulins and glucose were consistent with protected adrenocortical activation.

Item Type:Article
Keywords:antioxidants, adrenals, immunity, toxaemia
Subjects:Science > Biology > Biochemistry
Veterinary medicine > Diseases of special classes of animals > Sheep and goats
Live Archive:17 Apr 2024 01:49
Last Modified:17 Apr 2024 01:49

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