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Comparative immunogenicity of two bivalent botulinum vaccines

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Brown, A.T., Gregory, A.R., Ellis, T.M. and Hearnden, M.N. (1999) Comparative immunogenicity of two bivalent botulinum vaccines. Australian Veterinary Journal, 77 (6). pp. 388-391. ISSN 0005-0423

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Article Link: https://doi.org/10.1111/j.1751-0813.1999.tb10314.x


Objective: To compare the ability of a new single-dose botulinum vaccine containing a non-mineral oil adjuvant with a single dose of a conventional botulinum vaccine product to produce antibody to Clostridium botulinum types C and D in cattle in Northern Australia.

Design and procedure: One hundred and fifty Brahman steer weaners were randomly divided into two groups receiving either a single dose of CSL Bivalent Botulinum vaccine or Websters Singvac. Blood samples were collected at 0, 8 and 24 weeks and tested by antibody ELISA. The final samples were also tested by the toxin neutralisation test, to test titres of neutralising antibody.

Results: Six months after inoculation, cattle vaccinated with Websters Singvac had ELISA antibody response twice that of CSL conventional product. However, this difference was only evident for neutralising antibody to type C botulinum toxin. Both products produced similar titres of type D neutralising antibody after a single dose.

Conclusion: Websters' Singvac produces a greater neutralising antibody response to type C botulism upon single inoculation than a conventional vaccine. The product produces an equivalent neutralising antibody response to type D.

Item Type:Article
Subjects:Science > Microbiology > Immunology
Veterinary medicine > Diseases of special classes of animals > Cattle
Live Archive:06 Mar 2024 00:37
Last Modified:06 Mar 2024 00:37

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