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New insights into the altered adhesive and mechanical properties of red blood cells parasitized by Babesia bovis

Hutchings, C.L. and Li, A. and Fernandez, K.M. and Fletcher, T. and Jackson, L.A. and Molloy, J.B. and Jorgensen, W.K. and Lim, C.T. and Cooke, B.M. (2007) New insights into the altered adhesive and mechanical properties of red blood cells parasitized by Babesia bovis. Molecular Microbiology, 65 (4). pp. 1092-1105.

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Article Link(s): http://dx.doi.org/10.1111/j.1365-2958.2007.05850.x

Publisher URL: http://www3.interscience.wiley.com/cgi-bin/home

Abstract

Sequestration of parasite-infected red blood cells (RBCs) in the microvasculature is an important pathological feature of both bovine babesiosis caused by Babesia bovis and human malaria caused by Plasmodium falciparum. Surprisingly, when compared with malaria, the cellular and molecular mechanisms that underlie this abnormal circulatory behaviour for RBCs infected with B. bovis have been relatively ignored. Here, we present some novel insights into the adhesive and mechanical changes that occur in B. bovis-infected bovine RBCs and compare them with the alterations that occur in human RBCs infected with P. falciparum. After infection with B. bovis, bovine RBCs become rigid and adhere to vascular endothelial cells under conditions of physiologically relevant flow. These alterations are accompanied by the appearance of ridge-like structures on the RBC surface that are analogous, but morphologically and biochemically different, to the knob-like structures on the surface of human RBCs infected with P. falciparum. Importantly, albeit for a limited number of parasite lines examined here, the extent of these cellular and rheological changes appear to be related to parasite virulence. Future investigations to identify the precise molecular composition of ridges and the proteins that mediate adhesion will provide important insight into the pathogenesis of both babesiosis and malaria.

Item Type:Article
Corporate Creators:Biosecurity Queensland, Emerging Technologies
Additional Information:© The Authors. © Blackwell Publishing Ltd.
Keywords:Sequestration; red blood cells (RBCs); bovine babesiosis; Babesia bovis; human malaria; Plasmodium falciparum.
Subjects:Veterinary medicine > Veterinary pathology
Veterinary medicine > Veterinary parasitology
Science > Microbiology
Deposited On:05 Feb 2009 06:01
Last Modified:09 Sep 2010 06:50

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