Login | Request Account (DAF staff only)

Immunity following use of Australian tick fever vaccine: a review of the evidence

Share this record

Add to FacebookAdd to LinkedinAdd to XAdd to WechatAdd to Microsoft_teamsAdd to WhatsappAdd to Any

Export this record

View Altmetrics

Bock, R.E. and De Vos, A. J. (2001) Immunity following use of Australian tick fever vaccine: a review of the evidence. Australian Veterinary Journal, 79 (12). pp. 832-839. ISSN 0005-0423

Full text not currently attached. Access may be available via the Publisher's website or OpenAccess link.

Article Link: https://doi.org/10.1111/j.1751-0813.2001.tb10931.x


Objective: To review the evidence available on the degree and duration of immunity provided by Australian tick fever vaccines against Babesia bovis, B bigeminaand Anaplasma marginale infections in Australia and overseas.

Background: Vaccines containing attenuated strains of B bovis and B bigemina as well as A centrale grown in splenectomised calves have been used in Australia since 1964 to immunise cattle against tick fever. About 800,000 doses of vaccine are supplied annually and much of the evidence for protection is field evidence rather than conventional immunological measures or pen trials.

Conclusions: Immunity to Babesia bovis and B bigemina – A single inoculation generally provides sound, long-lasting protection both in Australia and overseas. No evidence was found of a loss of immunity with time. Vaccine failures to B bovis d o occur, but are uncommon and evidently caused by a number of factors, including immune responsiveness of the vaccinated animals, and immunogenicity of the vaccine strain.

Immunity to Anaplasma marginale– The vaccine containing A centrale provides partial, variable protection against A marginale. Protection against challenge in Australia is adequate in most cases to prevent disease and use of the vaccine in this country appears to be justified. Protection against antigenically diverse, highly virulent stocks of A marginale i n other countries is, at times, clearly inadequate and better vaccines are required in situations where the challenge is severe.

Item Type:Article
Subjects:Veterinary medicine > Veterinary epidemiology. Epizootiology
Live Archive:09 Jan 2024 04:20
Last Modified:09 Jan 2024 04:20

Repository Staff Only: item control page