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A blowfly strike vaccine requires an understanding of host-pathogen interactions

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Elkington, R.A. and Mahony, T.J. (2007) A blowfly strike vaccine requires an understanding of host-pathogen interactions. Vaccine, 25 (28). pp. 5133-5145.

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Article Link: http://dx.doi.org/10.1016/j.vaccine.2007.04.074

Publisher URL: http://www.elsevier.com


The phase-out of Mulesing by 2010 means the Australian wool industry requires immediate and viable alternatives for the control and prevention of blowfly strike, an economically important parasitic disease of sheep. In this review we have analysed previous research aimed toward the development of a vaccine against blowfly strike and the reasons why the approaches taken were unsuccessful at the time. Close scrutiny has provided new insight into this host-parasite interaction and identified new opportunities for the development of a vaccine. Here we propose that addressing immunosuppression together with the induction of cellular immunity is likely to result in an anti-blowfly strike vaccine, as opposed to the use of "standard" approaches aimed at inducing humoral immunity.

Item Type:Article
Corporate Creators:Emerging Technologies
Additional Information:© Crown Copyright. © Elsevier Ltd.
Keywords:Lucilia cuprina; immune response; immunosuppression; vaccine.
Subjects:Science > Science (General)
Animal culture > Sheep > Wool production
Veterinary medicine > Veterinary parasitology
Live Archive:03 Feb 2009 02:44
Last Modified:03 Sep 2021 16:47

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