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Simulating the Yield Impacts of Organ-Level Quantitative Trait Loci Associated With Drought Response in Maize: A “Gene-to-Phenotype” Modeling Approach

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Chenu, K., Chapman, S. C., Tardieu, F., McLean, G., Welcker, C. and Hammer, G. L. (2009) Simulating the Yield Impacts of Organ-Level Quantitative Trait Loci Associated With Drought Response in Maize: A “Gene-to-Phenotype” Modeling Approach. Genetics, 183 (4). pp. 1507-1523. ISSN 1943-2631

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Article Link: https://doi.org/10.1534/genetics.109.105429


Under drought, substantial genotype–environment (G × E) interactions impede breeding progress for yield. Identifying genetic controls associated with yield response is confounded by poor genetic correlations across testing environments. Part of this problem is related to our inability to account for the interplay of genetic controls, physiological traits, and environmental conditions throughout the crop cycle. We propose a modeling approach to bridge this “gene-to-phenotype” gap. For maize under drought, we simulated the impact of quantitative trait loci (QTL) controlling two key processes (leaf and silk elongation) that influence crop growth, water use, and grain yield. Substantial G × E interaction for yield was simulated for hypothetical recombinant inbred lines (RILs) across different seasonal patterns of drought. QTL that accelerated leaf elongation caused an increase in crop leaf area and yield in well-watered or preflowering water deficit conditions, but a reduction in yield under terminal stresses (as such “leafy” genotypes prematurely exhausted the water supply). The QTL impact on yield was substantially enhanced by including pleiotropic effects of these QTL on silk elongation and on consequent grain set. The simulations obtained illustrated the difficulty of interpreting the genetic control of yield for genotypes influenced only by the additive effects of QTL associated with leaf and silk growth. The results highlight the potential of integrative simulation modeling for gene-to-phenotype prediction and for exploiting G × E interactions for complex traits such as drought tolerance.

Item Type:Article
Business groups:Crop and Food Science
Subjects:Science > Statistics > Simulation modelling
Science > Botany > Genetics
Agriculture > Agriculture (General) > Agricultural meteorology. Crops and climate
Agriculture > Agriculture (General) > Methods and systems of culture. Cropping systems
Plant culture > Field crops > Corn. Maize
Live Archive:02 Feb 2022 03:12
Last Modified:02 Feb 2022 03:12

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