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Changes in Antibiotic Distribution Due to Pancreatitis

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Fanning, K. J., Robertson, T. A., Prins, J. B. and Roberts, M. S. (2011) Changes in Antibiotic Distribution Due to Pancreatitis. Antimicrobial Agents and Chemotherapy, 55 (6). pp. 3008-3011.

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Article Link: http://doi.org/10.1128/aac.00416-10

Publisher URL: http://aac.asm.org/content/55/6/3008.abstract


This work sought to define how pancreatitis affected antibiotic distribution in a perfused rat pancreas model. The distribution kinetics of four antibiotics were examined in control animals and animals with pancreatitis. Meropenem and piperacillin distributed into the extracellular space, and their distribution kinetics were unaffected by pancreatitis. In contrast, in pancreatic cells from animals with pancreatitis, ciprofloxacin showed a reduced uptake and clindamycin showed a reduced distribution.

Item Type:Article
Subjects:Science > Science (General)
Science > Physiology > Animal biochemistry
Veterinary medicine > Veterinary medicine of special organs, regions and systems
Live Archive:27 Mar 2019 03:58
Last Modified:03 Sep 2021 16:45

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