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Local immune response against larvae of Rhipicephalus (Boophilus) microplus in Bos taurus indicus and Bos taurus taurus cattle.

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Constantinoiu, C.C., Jackson, L. A., Jorgensen, W.K., Lew-Tabor, A.E., Piper, E.K., Mayer, D. G., Venus, B. and Jonsson, N.N. (2010) Local immune response against larvae of Rhipicephalus (Boophilus) microplus in Bos taurus indicus and Bos taurus taurus cattle. International Journal for Parasitology, 40 (7). pp. 865-875.

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Article Link: http://dx.doi.org/10.1016/j.ijpara.2010.01.004

Publisher URL: http://www.elsevier.com


Bos taurus indicus cattle are less susceptible to infestation with Rhipicephalus (Boophilus) microplus than Bos taurus taurus cattle but the immunological basis of this difference is not understood. We compared the dynamics of leukocyte infiltrations (T cell subsets, B cells, major histocompatibility complex (MHC) class II-expressing cells, granulocytes) in the skin near the mouthparts of larvae of R. microplus in B. t. indicus and B. t. taurus cattle. Previously naïve cattle were infested with 50,000 larvae (B. t. indicus) or 10,000 larvae (B. t. taurus) weekly for 6 weeks. One week after the last infestation all of the animals were infested with 20,000 larvae of R. microplus. Skin punch biopsies were taken from all animals on the day before the primary infestation and from sites of larval attachment on the day after the first, second, fourth and final infestations. Infiltrations with CD3+, CD4+, CD8+ and [gamma][delta] T cells followed the same pattern in both breeds, showing relatively little change during the first four weekly infestations, followed by substantial increases at 7 weeks post-primary infestation. There was a tendency for more of all cell types except granulocytes to be observed in the skin of B. t. indicus cattle but the differences between the two breeds were consistently significant only for [gamma][delta] T cells. Granulocyte infiltrations increased more rapidly from the day after infestation and were higher in B. t. taurus cattle than in B. t. indicus. Granulocytes and MHC class II-expressing cells infiltrated the areas closest to the mouthparts of larvae. A large volume of granulocyte antigens was seen in the gut of attached, feeding larvae.

Item Type:Article
Business groups:Biosecurity Queensland, Animal Science
Additional Information:© Australian Society for Parasitology Inc. © Elsevier.
Keywords:Rhipicephalus (Boophilus) microplus; host immune response; Bos taurus taurus; Bos taurus indicus; immunohistochemistry; skin; cattle.
Subjects:Science > Zoology > Invertebrates > Insects
Veterinary medicine > Veterinary parasitology
Veterinary medicine > Diseases of special classes of animals > Cattle
Live Archive:18 May 2010 07:55
Last Modified:04 Jan 2024 02:41

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