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(E)-5-(2′-bromovinyl)-2′-deoxyuridine inhibition of macropodid herpesvirus 1 in vitro

Smith, G. A. and Whalley, J. M. (1998) (E)-5-(2′-bromovinyl)-2′-deoxyuridine inhibition of macropodid herpesvirus 1 in vitro. Journal of Zoo and Wildlife Medicine, 29 (2). pp. 157-159. ISSN 1042-7260

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Article Link: https://www.jstor.org/stable/20095738


Herpesviruses have caused the death of kangaroos and wallabies in European and North American zoos. Eight antiherpetic purine or pyrmidine nucleoside compounds were tested in plaque reduction neutralization tests for in vitro inhibition of macropodid herpesvirus 1, a virus that has been associated with illness in captive macropods in Australia. The virus was most susceptible to inhibition by (E)-5-(2′-bromovinyl)-2′-deoxyuridine (BVDU) and 5′-iodo-2′-deoxycytidine. Because BVDU effectively inhibits macropodid herpesvirus 2 in vitro, it may be the drug of choice for experimental therapy in herpesvirus infections in captive macropodids.

Item Type:Article
Subjects:Science > Zoology > Chordates. Vertebrates > Mammals > Marsupialia. Marsupials > Diprotodontia (Kangaroos, koalas, possums, wombats, bilbies etc)
Veterinary medicine > Veterinary epidemiology. Epizootiology
Live Archive:17 Mar 2024 23:05
Last Modified:17 Mar 2024 23:05

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