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Investigations of breakdowns in protection provided by living Babesia bovis vaccine

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Bock, R.E., De Vos, A. J., Kingston, T.G., Shiels, I.A. and Dalgliesh, R.J. (1992) Investigations of breakdowns in protection provided by living Babesia bovis vaccine. Veterinary Parasitology, 43 (1-2). pp. 45-56. ISSN 0304-4017

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Article Link: https://doi.org/10.1016/0304-4017(92)90047-D


Field investigations of protection afforded by live Babesia bovis vaccine in Australia revealed that a ninefold increase in vaccine failures occured in the period from 1985 to 1990. Laboratory trials using 189 experimental cattle were conducted to evaluate the protection afforded by the Babesia bovis strain used in the commercial vaccine during this time. Four isolates from clinical cases of babesiosis in vaccinated cattle were assessed. The results showed that the strain used in the vaccine during the 5 year period was poorly protective against three isolates while a recently isolated and prepared vaccine strain was strongly protective. Circumstantial evidence is provided that indicates the vaccine failures were due to change in the field populations of Babesia bovis, rather than change in the strain used in the vaccine. Implications of the results for the future of Babesia bovis vaccines are discussed.

Item Type:Article
Subjects:Veterinary medicine > Veterinary parasitology
Veterinary medicine > Diseases of special classes of animals > Cattle
Live Archive:16 Feb 2024 01:55
Last Modified:16 Feb 2024 01:55

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