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Cedar Virus: A Novel Henipavirus Isolated from Australian Bats

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Marsh, G. A., de Jong, C. E., Barr, J. A., Tachedjian, M., Smith, C. S., Middleton, D., Yu, M., Todd, S., Foord, A. J., Haring, V., Payne, J., Robinson, R., Broz, I., Crameri, G., Field, H. E. and Wang, L.-F. (2012) Cedar Virus: A Novel Henipavirus Isolated from Australian Bats. PLOS Pathogens, 8 (8). e1002836.

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Article Link: https://doi.org/10.1371/journal.ppat.1002836

Abstract

Author Summary Hendra and Nipah viruses are 2 highly pathogenic paramyxoviruses that have emerged from bats within the last two decades. Both are capable of causing fatal disease in both humans and many mammal species. Serological and molecular evidence for henipa-like viruses have been reported from numerous locations including Asia and Africa, however, until now no successful isolation of these viruses have been reported. This paper reports the isolation of a novel paramyxovirus, named Cedar virus, from fruit bats in Australia. Full genome sequencing of this virus suggests a close relationship with the henipaviruses. Antibodies to Cedar virus were shown to cross react with, but not cross neutralize Hendra or Nipah virus. Despite this close relationship, when Cedar virus was tested in experimental challenge models in ferrets and guinea pigs, we identified virus replication and generation of neutralizing antibodies, but no clinical disease was observed. As such, this virus provides a useful reference for future reverse genetics experiments to determine the molecular basis of the pathogenicity of the henipaviruses.

Item Type:Article
Corporate Creators:Department of Agriculture and Fisheries, Queensland
Business groups:Biosecurity Queensland
Subjects:Veterinary medicine > Veterinary virology
Veterinary medicine > Veterinary epidemiology. Epizootiology
Veterinary medicine > Communicable diseases of animals (General)
Live Archive:04 Jan 2024 22:47
Last Modified:04 Jan 2024 22:47

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