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Vaccination against bovine babesiosis

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De Vos, A. J. and Bock, R.E. (2000) Vaccination against bovine babesiosis. Annals of the New York Academy of Science, 916 (1). pp. 540-545. ISSN 1749-6632

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Article Link: https://doi.org/10.1111/j.1749-6632.2000.tb05333.x


Bovine babesiosis is an important disease caused by Babesia bovis, B. bigemina, and B. divergens. Solid immunity develops after infection and this feature has been exploited with the use of live attenuated organisms as immunogens. Attributes of live vaccines include a durable immunity to heterologous challenge after one vaccination. To overcome disadvantages relating to poor quality control (risk of contamination and adverse reactions), production procedures have been modified to meet the requirements of codes of good manufacturing practice. This includes development of methods to allow production of cryopreserved vaccine and limit antigenic drift. Killed vaccines have also been used on a limited basis and consist of antigens extracted from cultured material or blood of infected calves, and given with adjuvant. The degree and duration of immunity against heterologous challenge is not well documented. Attempts are being made to develop subunit vaccines but the progress has been slow. A better understanding of the mechanisms involved in the expression of protective immunity against Babesia spp will aid in the identification of protective antigens.

Item Type:Article
Subjects:Veterinary medicine > Diseases of special classes of animals > Cattle
Live Archive:04 Jan 2024 01:12
Last Modified:04 Jan 2024 01:12

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