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Detection and Characterisation of an Endogenous Betaretrovirus in Australian Wild Deer

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Huaman, J. L., Pacioni, C., Forsyth, D. M., Pople, A. R., Hampton, J. O., Carvalho, T. G. and Helbig, K. J. (2022) Detection and Characterisation of an Endogenous Betaretrovirus in Australian Wild Deer. Viruses, 14 (2). p. 252. ISSN 1999-4915

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Article Link(s): https://doi.org/10.3390/v14020252

Publisher URL: https://www.mdpi.com/1999-4915/14/2/252

Abstract

Endogenous retroviruses (ERVs) are the remnants of past retroviral infections that once invaded the host’s germline and were vertically transmitted. ERV sequences have been reported in mammals, but their distribution and diversity in cervids are unclear. Using next-generation sequencing, we identified a nearly complete genome of an endogenous betaretrovirus in fallow deer (Dama dama). Further genomic analysis showed that this provirus, tentatively named cervid endogenous betaretrovirus 1 (CERV β1), has typical betaretroviral genome features (gag-pro-pol-env) and the betaretrovirus-specific dUTPase domain. In addition, CERV β1 pol sequences were detected by PCR in the six non-native deer species with wild populations in Australia. Phylogenetic analyses demonstrated that CERV β1 sequences from subfamily Cervinae clustered as sister taxa to ERV-like sequences in species of subfamily Muntiacinae. These findings, therefore, suggest that CERV β1 endogenisation occurred after the split of these two subfamilies (between 3.3 and 5 million years ago). Our results provide important insights into the evolution of betaretroviruses in cervids.

Item Type:Article
Business groups:Biosecurity Queensland
Keywords:betaretrovirus; class II retroviruses; deer; endogenous retroviruses; genetic characterisation
Subjects:Science > Invasive Species > Animals
Animal culture > Deer
Veterinary medicine > Veterinary virology
Deposited On:10 Feb 2022 06:22
Last Modified:10 Feb 2022 06:22

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