Login | Request Account (DAF staff only)

Human Hendra Virus Encephalitis Associated with Equine Outbreak, Australia, 2008

View Altmetrics

Playford, E. G., McCall, B., Smith, G., Slinko, V., Allen, G., Smith, I., Moore, F., Taylor, C., Kung, Y.-H. and Field, H. (2010) Human Hendra Virus Encephalitis Associated with Equine Outbreak, Australia, 2008. Emerging Infectious Disease journal, 16 (2). p. 219. ISSN 1080-6059

[img]
Preview
PDF
136kB
[img]
Preview
PDF (Appendix table)
41kB

Article Link(s): https://doi.org/10.3201/eid1602.090552

Publisher URL: https://wwwnc.cdc.gov/eid/article/16/2/09-0552_article

Abstract

A recent Hendra virus outbreak at a veterinary clinic in Brisbane, Queensland, Australia, involved 5 equine and 2 human infections. In contrast to previous outbreaks, infected horses had predominantly encephalitic, rather than respiratory, signs. After an incubation period of 9–16 days, influenza-like illnesses developed in the 2 persons before progressing to encephalitis; 1 died. Both patients were given ribavirin. Basal serum and cerebrospinal fluid levels were 10–13 mg/L after intravenous administration and 6 mg/L after oral administration (isolate 90% inhibitory concentration 64 mg/L). Both patients were exposed to infected horses, 1 during the late incubation period in a horse. The attack rate for veterinary clinic staff exposed to infected horses was 10%. An isolate from this outbreak showed genetic heterogeneity with isolates from a concurrent, but geographically remote, outbreak and from previous outbreaks. Emergence of Hendra virus is a serious medical, veterinary, and public health challenge.

Item Type:Article
Business groups:Biosecurity Queensland
Additional Information:Open access
Keywords:Australia encephalitis equines Hendra virus Henipavirus Paramyxoviridae research ribavirin viruses
Subjects:Veterinary medicine > Veterinary virology
Veterinary medicine > Veterinary epidemiology. Epizootiology
Veterinary medicine > Communicable diseases of animals (General)
Deposited On:10 Dec 2020 05:32
Last Modified:10 Dec 2020 05:32

Repository Staff Only: item control page

Downloads

Downloads per month over past year

View more statistics