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Pteropid bats are confirmed as the reservoir hosts of henipaviruses: A comprehensive experimental study of virus transmission

Halpin, K., Hyatt, A. D., Fogarty, R., Middleton, D., Bingham, J., Epstein, J. H., Rahman, S. A., Hughes, T., Smith, C., Field, H. E. and Daszak, P. (2011) Pteropid bats are confirmed as the reservoir hosts of henipaviruses: A comprehensive experimental study of virus transmission. American Journal of Tropical Medicine and Hygiene, 85 (5). pp. 946-951. ISSN 00029637 (ISSN)

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Article Link(s): http://doi.org/10.4269/ajtmh.2011.10-0567

Publisher URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-81155131372&doi=10.4269%2fajtmh.2011.10-0567&partnerID=40&md5=6cd8476536cd2cb67a32604f3707467f

Abstract

Bats of the genus Pteropus have been identified as the reservoir hosts for the henipaviruses Hendra virus (HeV) and Nipah virus (NiV). The aim of these studies was to assess likely mechanisms for henipaviruses transmission from bats. In a series of experiments, Pteropus bats from Malaysia and Australia were inoculated with NiV and HeV, respectively, by natural routes of infection. Despite an intensive sampling strategy, no NiV was recovered from the Malaysian bats and HeV was reisolated from only one Australian bat; no disease was seen. These experiments suggest that opportunities for henipavirus transmission may be limited; therefore, the probability of a spillover event is low. For spillover to occur, a range of conditions and events must coincide. An alternate assessment framework is required if we are to fully understand how this reservoir host maintains and transmits not only these but all viruses with which it has been associated. Copyright © 2011 by The American Society of Tropical Medicine and Hygiene.

Item Type:Article
Keywords:animal experiment animal model article Australia bat controlled study female gender Hendra virus Henipavirus infection host infection sensitivity inoculation Malaysia male Nipah virus nonhuman pregnancy probability Pteropus alecto reservoir virus isolation virus transmission Animals Chiroptera Disease Reservoirs Genome, Viral Henipavirus Infections Henipavirus Pteropus
Subjects:Veterinary medicine > Veterinary virology
Deposited On:28 Mar 2019 00:04
Last Modified:28 Mar 2019 00:04

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