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Divergent human-origin influenza viruses detected in Australian swine populations

Wong, F. Y. K., Donato, C., Deng, Y. M., Teng, D., Komadina, N., Baas, C., Modak, J., O'Dea, M., Smith, D. W., Effler, P. V., Cooke, J., Davies, K. R., Hurt, A., Kung, N., Levy, A., Loh, R., Shan, S., Shinwari, M. W., Stevens, V., Taylor, J., Williams, D. T., Watson, J., Eagles, D., McCullough, S., Barr, I. G. and Dhanasekaran, V. (2018) Divergent human-origin influenza viruses detected in Australian swine populations. Journal of Virology, 92 (16). ISSN 0022538X (ISSN)

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Article Link(s): http://doi.org/10.1128/JVI.00316-18

Abstract

Global swine populations infected with influenza A viruses pose a persistent pandemic risk. With the exception of a few countries, our understanding of the genetic diversity of swine influenza viruses is limited, hampering control measures and pandemic risk assessment. Here we report the genomic characteristics and evolutionary history of influenza A viruses isolated in Australia from 2012 to 2016 from two geographically isolated swine populations in the states of Queensland and Western Australia. Phylogenetic analysis with an expansive human and swine influenza virus data set comprising > 40,000 sequences sampled globally revealed evidence of the pervasive introduction and long-term establishment of gene segments derived from several human influenza viruses of past seasons, including the H1N1/ 1977, H1N1/1995, H3N2/1968, and H3N2/2003, and the H1N1 2009 pandemic (H1N1pdm09) influenza A viruses, and a genotype that contained gene segments derived from the past three pandemics (1968, reemerged 1977, and 2009). Of the six human-derived gene lineages, only one, comprising two viruses isolated in Queensland during 2012, was closely related to swine viruses detected from other regions, indicating a previously undetected circulation of Australian swine lineages for approximately 3 to 44 years. Although the date of introduction of these lineages into Australian swine populations could not be accurately ascertained, we found evidence of sustained transmission of two lineages in swine from 2012 to 2016. The continued detection of human-origin influenza virus lineages in swine over several decades with little or unpredictable antigenic drift indicates that isolated swine populations can act as antigenic archives of human influenza viruses, raising the risk of reemergence in humans when sufficient susceptible populations arise. © 2018 American Society for Microbiology.

Item Type:Article
Business groups:Animal Science
Keywords:Antigenicity Influenza surveillance Pandemic risk Phylogenetic analysis Reassortment Swine influenza 2009 H1N1 influenza animal tissue Article genetic variability genotype Influenza A virus Influenza A virus (H1N1) Influenza A virus (H3N2) molecular evolution nonhuman phylogeny pig priority journal Queensland sequence analysis virus detection virus genome virus isolation virus transmission Western Australia animal classification genetic variation genetics human isolation and purification molecular epidemiology orthomyxovirus infection swine disease veterinary virology Animals Humans Orthomyxoviridae Infections Swine Swine Diseases
Subjects:Animal culture > Swine
Veterinary medicine > Veterinary virology
Veterinary medicine > Diseases of special classes of animals > Swine
Deposited On:17 Jan 2019 02:28
Last Modified:30 May 2019 05:32

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