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Clay Nanoparticles Elicit Long‐Term Immune Responses by Forming Biodegradable Depots for Sustained Antigen Stimulation

Weiyu, Chen and Huali, Zuo and Bei, Li and Chengcheng, Duan and Barbara, Rolfe and Bing, Zhang and J., Mahony Timothy and Ping, Xu Zhi (2018) Clay Nanoparticles Elicit Long‐Term Immune Responses by Forming Biodegradable Depots for Sustained Antigen Stimulation. Small, 14 (19). p. 1704465.

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Article Link(s): https://doi.org/10.1002/smll.201704465

Publisher URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.201704465

Abstract

Abstract Nanomaterials have been widely tested as new generation vaccine adjuvants, but few evoke efficient immunoreactions. Clay nanoparticles, for example, layered double hydroxide (LDH) and hectorite (HEC) nanoparticles, have shown their potent adjuvanticity in generating effective and durable immune responses. However, the mechanism by which clay nanoadjuvants stimulate the immune system is not well understood. Here, it is demonstrated that LDH and HEC–antigen complexes form loose agglomerates in culture medium/serum. They also form nodules with loose structures in tissue after subcutaneous injection, where they act as a depot for up to 35 d. More importantly, clay nanoparticles actively and continuously recruit immune cells into the depot for up to one month, and stimulate stronger immune responses than FDA‐approved adjuvants, Alum and QuilA. Sustained antigen release is also observed in clay nanoparticle depots, with 50–60% antigen released after 35 d. In contrast, Alum–antigen complexes show minimal antigen release from the depot. Importantly, LDH and HEC are more effective than QuilA and Alum in promoting memory T‐cell proliferation. These findings suggest that both clay nanoadjuvants can serve as active vaccine platforms for sustained and potent immune responses.

Item Type:Article
Business groups:Animal Science
Subjects:Science > Biology > Biochemistry
Science > Biology > Molecular Biology
Agriculture > Agriculture (General) > Agricultural chemistry. Agricultural chemicals
Deposited On:26 Jun 2018 05:11
Last Modified:26 Jun 2018 05:11

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