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Vaccine Adjuvants: Efficient and Durable Vaccine against Intimin β of Diarrheagenic E. Coli Induced by Clay Nanoparticles

Chen, Weiyu and Zhang, Bing and Mahony, Timothy and Gu, Wenyi and Rolfe, Barbara and Xu, Zhi Ping (2016) Vaccine Adjuvants: Efficient and Durable Vaccine against Intimin β of Diarrheagenic E. Coli Induced by Clay Nanoparticles. Small, 12 (12). p. 1541. ISSN 1613-6829

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Article Link(s): http://dx.doi.org/10.1002/smll.201670058

Publisher URL: http://onlinelibrary.wiley.com/store/10.1002/smll.201670058/asset/smll201670058.pdf?v=1&t=ixqx5xrt&s=6229d6772c6e19468eb2d348f9bd59da960d6853

Abstract

On page 1627, layered double hydroxide (hexagonal) and hectorite (sheet) nanoparticles are demonstrated to be promising vaccine adjuvants by T. Mahony, Z. P. Xu, and co-workers. The nanoparticles induce sustained, high levels of specific antibodies (IgG and IgA) and a strong cell-mediated response (IFN-γ), in comparison with the commonly-used adjuvant QuilA. Their high adjuvanticity could be attributed to the high antigen loading, facilitation to the antigen cellular uptake and the depot effect.

Item Type:Article
Business groups:Animal Science
Keywords:clay nanoparticles hectorite intimin β layered double hydroxides vaccine adjuvants
Subjects:Veterinary medicine > Veterinary bacteriology
Veterinary medicine > Communicable diseases of animals (General)
Deposited On:16 Jan 2017 23:26
Last Modified:16 Jan 2017 23:26

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