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Variation in the antimicrobial susceptibility of actinobacillus pleuropneumoniae isolates in a pig, within a batch of pigs, and among batches of pigs from one farm

Dayao, D. A. and Dawson, S. and Kienzle, M. J. and Gibson, J. S. and Blackall, P. J. and Turni, C. (2015) Variation in the antimicrobial susceptibility of actinobacillus pleuropneumoniae isolates in a pig, within a batch of pigs, and among batches of pigs from one farm. Microbial Drug Resistance, 21 (4). pp. 491-6. ISSN 1076-6294

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Article Link(s): http://dx.doi.org/10.1089/mdr.2014.0265

Abstract

Antimicrobial resistance in bacterial porcine respiratory pathogens has been shown to exist in many countries. However, little is known about the variability in antimicrobial susceptibility within a population of a single bacterial respiratory pathogen on a pig farm. This study examined the antimicrobial susceptibility of Actinobacillus pleuropneumoniae using multiple isolates within a pig and across the pigs in three different slaughter batches. Initially, the isolates from the three batches were identified, serotyped, and subsample genotyped. All the 367 isolates were identified as A. pleuropneumoniae serovar 1, and only a single genetic profile was detected in the 74 examined isolates. The susceptibility of the 367 isolates of A. pleuropneumoniae to ampicillin, tetracycline and tilmicosin was determined by a disc diffusion technique. For tilmicosin, the three batches were found to consist of a mix of susceptible and resistant isolates. The zone diameters of the three antimicrobials varied considerably among isolates in the second sampling. In addition, the second sampling provided statistically significant evidence of bimodal populations in terms of zone diameters for both tilmicosin and ampicillin. The results support the hypothesis that the antimicrobial susceptibility of one population of a porcine respiratory pathogen can vary within a batch of pigs on a farm.

Item Type:Article
Business groups:Animal Science
Additional Information:1931-8448 Dayao, Denise Ann E Dawson, Susan Kienzle, Marco Jean-Paul Gibson, Justine S Blackall, Patrick J Turni, Conny Journal Article Research Support, Non-U.S. Gov't United States Microb Drug Resist. 2015 Aug;21(4):491-6. doi: 10.1089/mdr.2014.0265. Epub 2015 Feb 24.
Subjects:Animal culture > Swine
Veterinary medicine > Veterinary microbiology
Deposited On:09 Feb 2016 02:30
Last Modified:06 Apr 2016 02:37

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