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In vitro degradation of hepatotoxic indospicine in indigofera spicata by camel foregut fluid

Tan, E.T.T., Fletcher, M. T., D'arcy, B.R. and Al Jassim, R. (2015) In vitro degradation of hepatotoxic indospicine in indigofera spicata by camel foregut fluid. In: 4th international conference of ISOCARD, 2015, Almaty Kazakhstan.

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Indospicine toxicosis was reported in sheep, goats and cattle fed on Indigofera, a leguminous plant rich in indospicine. Recent death report on dogs as a result of dietary ingestion of indospicine contaminated camel meat has raised concern about the distribution of this toxin in camels fed on Indigofera. This in vitro study aimed at measuring the degradability of indospicine in Indigofera spicata by camel-foregut fluid and attempted at explaining indospicine accumulation in meat tissue. In the first experiment, in vitro dry matter digestibility and indospicine disappearance were evaluated by using foregut fluid from 15 feral camels. Foregut fluid was collected post mortem from a nearby abattoir. In the second experiment, a composite foregut fluid obtained from three feral camels was used to examine the time-dependent degradation of indospicine. Results indicated that 99 of the dietary indospicine was degraded after 48 h of incubation. The time-dependent degradation study showed rapid degradation (11 µg/h) during the first 18 h of incubation, followed by a much slower rate (2 µg/h) between 18-48 h. Results demonstrated the ability of the camel microbiota to degrade indospicine and suggest the presence of a by-pass mechanism that enables the toxin to escape degradation and reaches the intestine.

Item Type:Conference or Workshop Item (Paper)
Business groups:Animal Science
Subjects:Animal culture
Animal culture > Other domesticated and semi-domesticated animals
Veterinary medicine > Veterinary microbiology
Live Archive:13 Aug 2015 07:08
Last Modified:03 Sep 2021 16:50

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