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Evaluation and histological examination of a Campylobacter fetus subsp. venerealis small animal infection model

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Koya, A., de Wet, S. C., Turner, S., Cawdell-Smith, J., Venus, B., Greer, R. M., Lew-Tabor, A. E. and Boe-Hansen, G. B. (2015) Evaluation and histological examination of a Campylobacter fetus subsp. venerealis small animal infection model. Research in Veterinary Science, 99 . pp. 1-9.

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Article Link: http://dx.doi.org/10.1016/j.rvsc.2014.12.005

Publisher URL: http://www.sciencedirect.com/science/article/pii/S0034528814003464

Abstract

Bovine genital campylobacteriosis (BGC), caused by Campylobacter fetus subsp. venerealis, is associated with production losses in cattle worldwide. This study aimed to develop a reliable BGC guinea pig model to facilitate future studies of pathogenicity, abortion mechanisms and vaccine efficacy. Seven groups of five pregnant guinea pigs (1 control per group) were inoculated with one of three strains via intra-peritoneal (IP) or intra-vaginal routes. Samples were examined using culture, PCR and histology. Abortions ranged from 0 to 100 and re-isolation of causative bacteria from sampled sites varied with strain, dose of bacteria and time to abortion. Histology indicated metritis and placentitis, suggesting that the bacteria induce inflammation, placental detachment and subsequent abortion. Variation of virulence between strains was observed and determined by culture and abortion rates. IP administration of C. fetus subsp. venerealis to pregnant guinea pigs is a promising small animal model for the investigation of BGC abortion.

Item Type:Article
Business groups:Biosecurity Queensland
Keywords:C. fetus subspecies venerealis Campylobacteriosis Placentitis Bovine Guinea pig
Subjects:Animal culture
Veterinary medicine > Veterinary microbiology
Veterinary medicine > Communicable diseases of animals (General)
Live Archive:13 Jul 2015 04:18
Last Modified:19 Oct 2021 06:03

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