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Crusted scabies is associated with increased IL-17 secretion by skin T cells

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Liu, X., Walton, S. F., Murray, H. C., King, M., Kelly, A., Holt, D. C., Currie, B. J., McCarthy, J. S. and Mounsey, K. E. (2014) Crusted scabies is associated with increased IL-17 secretion by skin T cells. Parasite Immunology, 36 (11). pp. 594-604. ISSN 1365-3024

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Article Link: http://dx.doi.org/10.1111/pim.12129

Abstract

Scabies is an ectoparasitic infestation by the mite Sarcoptes scabiei. Although commonly self-limiting, a fraction of patients develop severely debilitating crusted scabies. The immune mechanisms underlying the development of crusted scabies are unclear, and undertaking longitudinal infection studies in humans is difficult. We utilized a porcine model to compare cellular immune responses in peripheral blood and skin of pigs with different clinical manifestations of scabies (n = 12), and in uninfected controls (n = 6). Although clinical symptoms were not evident until at least 4 weeks post-infestation, the numbers of peripheral IFNγ-secreting CD4+ T cells and γδ T cells increased in infected pigs from week 1 post-infestation. γδ T cells remained increased in the blood at week 15 post-infestation. At week 15, skin cell infiltrates from pigs with crusted scabies had significantly higher CD8+ T cell, γδ T cell and IL-17+ cell numbers than those with ordinary scabies. Peripheral IL-17 levels were not increased, suggesting that localized skin IL-17-secreting T cells may play a critical role in the pathogenesis of crusted scabies development. Given the potential of anti-IL-17 immunotherapy demonstrated for other inflammatory skin diseases, this study may provide a novel therapeutic avenue for patients with recurrent crusted scabies.

Item Type:Article
Business groups:Animal Science
Keywords:crusted scabies IL-17 scabies γδ T cells
Subjects:Animal culture > Swine
Veterinary medicine > Veterinary parasitology
Live Archive:21 Jan 2015 06:03
Last Modified:07 Jun 2022 05:00

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