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Crusted scabies is associated with increased IL-17 secretion by skin T cells

Liu, X. and Walton, S. F. and Murray, H. C. and King, M. and Kelly, A. and Holt, D. C. and Currie, B. J. and McCarthy, J. S. and Mounsey, K. E. (2014) Crusted scabies is associated with increased IL-17 secretion by skin T cells. Parasite Immunology, 36 (11). pp. 594-604. ISSN 1365-3024

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Article Link(s): http://dx.doi.org/10.1111/pim.12129

Abstract

Scabies is an ectoparasitic infestation by the mite Sarcoptes scabiei. Although commonly self-limiting, a fraction of patients develop severely debilitating crusted scabies. The immune mechanisms underlying the development of crusted scabies are unclear, and undertaking longitudinal infection studies in humans is difficult. We utilized a porcine model to compare cellular immune responses in peripheral blood and skin of pigs with different clinical manifestations of scabies (n = 12), and in uninfected controls (n = 6). Although clinical symptoms were not evident until at least 4 weeks post-infestation, the numbers of peripheral IFNγ-secreting CD4+ T cells and γδ T cells increased in infected pigs from week 1 post-infestation. γδ T cells remained increased in the blood at week 15 post-infestation. At week 15, skin cell infiltrates from pigs with crusted scabies had significantly higher CD8+ T cell, γδ T cell and IL-17+ cell numbers than those with ordinary scabies. Peripheral IL-17 levels were not increased, suggesting that localized skin IL-17-secreting T cells may play a critical role in the pathogenesis of crusted scabies development. Given the potential of anti-IL-17 immunotherapy demonstrated for other inflammatory skin diseases, this study may provide a novel therapeutic avenue for patients with recurrent crusted scabies.

Item Type:Article
Business groups:Animal Science
Keywords:crusted scabies IL-17 scabies γδ T cells
Subjects:Animal culture > Swine
Veterinary medicine > Veterinary parasitology
Deposited On:21 Jan 2015 06:03
Last Modified:21 Jan 2015 06:03

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