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Association between feline immunodeficiency virus (FIV) plasma viral RNA load, concentration of acute phase proteins and disease severity

Kann, Rebecca K.C. and Seddon, Jennifer M. and Kyaw-Tanner, Myat T. and Henning, Joerg and Meers, Joanne (2014) Association between feline immunodeficiency virus (FIV) plasma viral RNA load, concentration of acute phase proteins and disease severity. The Veterinary Journal, 201 (2). p. 181. ISSN 10900233

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Article Link(s): http://dx.doi.org/10.1016/j.tvjl.2014.01.023

Abstract

Veterinarians have few tools to predict the rate of disease progression in FIV-infected cats. In contrast, in HIV infection, plasma viral RNA load and acute phase protein concentrations are commonly used as predictors of disease progression. This study evaluated these predictors in cats naturally infected with FIV. In older cats (>5 years), log10 FIV RNA load was higher in the terminal stages of disease compared to the asymptomatic stage. There was a significant association between log10 FIV RNA load and both log10 serum amyloid A concentration and age in unwell FIV-infected cats. This study suggests that viral RNA load and serum amyloid A warrant further investigation as predictors of disease status and prognosis in FIV-infected cats.

Item Type:Article
Business groups:Animal Science
Subjects:Veterinary medicine > Communicable diseases of animals (General)
Veterinary medicine > Veterinary virology
Deposited On:27 Aug 2014 03:31
Last Modified:28 Aug 2014 15:08

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