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Effect of Increasing Low Dose Simplexin Exposure in Cattle consuming Pimelia trychostachya

Fletcher, Mary T. and Chow, Sharon and Ossedryver, Selina (2014) Effect of Increasing Low Dose Simplexin Exposure in Cattle consuming Pimelia trychostachya. Journal of Agricultural and Food Chemistry . ISSN 0021-8561

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Article Link(s): http://dx.doi.org/10.1021/jf5005644

Abstract

Pimelea species (or desert riceflower) are small native plants endemic to the drier inland pastoral regions of Australia, which cause a unique syndrome in grazing cattle characterised by submandibular oedema and oedema in the brisket area as a result of right-sided heart failure attributed to the toxin simplexin. Field evidence suggests that poisoning can occur through minor, inadvertent consumption of Pimelea plant material, but the minimum simplexin intake required to induce Pimelea poisoning is not known. In this study, mild Pimelea poisoning was induced at a daily dose of 12.5 mg Pimelea/kg bodyweight per day, equivalent to 2.5 µg simplexin/kg bodyweight per day, demonstrating the high potential toxicity of these plant species. Effects in all animals diminished with prolonged low dose feeding and we postulate that these animals developed mechanisms for detoxifying simplexin, 1, possibly through rumen bacteria adaptation or activation of liver enzymes.

Item Type:Article
Business groups:Animal Science
Subjects:Animal culture > Cattle
Plant pests and diseases
Veterinary medicine > Veterinary bacteriology
Deposited On:01 Jul 2014 05:55
Last Modified:01 Jul 2014 05:57

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