Isolation and characterization of conopeptides by high-performance liquid chromatography combined with mass spectrometry and tandem mass spectrometry

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Jones, A., Bingham, J.-P., Gehrmann, J., Bond, T., Loughnan, M., Atkins, A., Lewis, R. J. and Alewood, P. F. (1996) Isolation and characterization of conopeptides by high-performance liquid chromatography combined with mass spectrometry and tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 10 (1). pp. 138-143. ISSN 1097-0231

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Article Link: https://doi.org/10.1002/(SICI)1097-0231(19960115)1...

Abstract

The sensitivity of mass spectrometry combined with the separatory power of high-performance liquid chromatography was used to investigate the venom of individual cone shells. This analysis has revealed that cone venoms contain a complex mixture of peptides which vary quantitatively and qualitatively both between and within species. A differential alkylation procedure followed by tandem mass spectrometric analysis can be used to determine the disulfide bond connectivity in these small, cysteine-rich peptides.

Item Type:	Article
Subjects:	Technology > Technology (General) > Chromatography > Liquid chromatography Science > Zoology > Invertebrates Veterinary medicine > Veterinary toxicology
Live Archive:	10 Apr 2024 23:08
Last Modified:	10 Apr 2024 23:08

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