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Characterisation of the Upper Respiratory Tract Virome of Feedlot Cattle and Its Association with Bovine Respiratory Disease

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Ambrose, R. K., Blakebrough-Hall, C., Gravel, J. L., Gonzalez, L. A. and Mahony, T. J. (2023) Characterisation of the Upper Respiratory Tract Virome of Feedlot Cattle and Its Association with Bovine Respiratory Disease. Viruses, 15 (2). p. 455. ISSN 1999-4915

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Article Link: https://doi.org/10.3390/v15020455

Publisher URL: https://www.mdpi.com/1999-4915/15/2/455


Bovine respiratory disease (BRD) is a major health problem within the global cattle industry. This disease has a complex aetiology, with viruses playing an integral role. In this study, metagenomics was used to sequence viral nucleic acids in the nasal swabs of BRD-affected cattle. The viruses detected included those that are well known for their association with BRD in Australia (bovine viral diarrhoea virus 1), as well as viruses known to be present but not fully characterised (bovine coronavirus) and viruses that have not been reported in BRD-affected cattle in Australia (bovine rhinitis, bovine influenza D, and bovine nidovirus). The nasal swabs from a case–control study were subsequently tested for 10 viruses, and the presence of at least one virus was found to be significantly associated with BRD. Some of the more recently detected viruses had inconsistent associations with BRD. Full genome sequences for bovine coronavirus, a virus increasingly associated with BRD, and bovine nidovirus were completed. Both viruses belong to the Coronaviridae family, which are frequently associated with disease in mammals. This study has provided greater insights into the viral pathogens associated with BRD and highlighted the need for further studies to more precisely elucidate the roles viruses play in BRD.

Item Type:Article
Corporate Creators:Department of Agriculture and Fisheries, Queensland
Business groups:Animal Science
Keywords:bovine respiratory disease; virome; bovine nidovirus; bovine coronavirus; bovine herpesvirus 1; bovine viral diarrhoea virus 1; bovine respiratory syncytial virus; case control; odds ratio
Subjects:Animal culture > Cattle
Veterinary medicine > Veterinary virology
Veterinary medicine > Diseases of special classes of animals
Live Archive:09 Apr 2024 05:50
Last Modified:09 Apr 2024 05:50

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