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Monooxygenases play only a minor role in resistance to synthetic pyrethroids in the cattle tick, Boophilus microplus

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Crampton, A.L., Green, P., Baxter, G.D. and Barker, S.C. (1999) Monooxygenases play only a minor role in resistance to synthetic pyrethroids in the cattle tick, Boophilus microplus. Experimental & Applied Acarology, 23 . pp. 897-905. ISSN 1572-9702

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Article Link: https://doi.org/10.1023/A:1006245800759

Abstract

We investigated the role of monooxygenases in resistance to synthetic pyrethroids (SPs) in the cattle tick, Boophilus microplus. We found that monooxygenases play only a minor role in resistance to SPs in both resistant and susceptible strains of B. microplus. We blocked the monooxygenases with piperonyl butoxide (PBO) and simultaneously applied the SPs, flumethrin and cypermethrin to larval B. microplus. PBO increased the effect of flumethrin (synergism ratios 2.7–8.9) more than it increased the effect of cypermethrin (synergism ratios 1.9–3.1). Of the four strains tested, Parkhurst, which is resistant to SPs, was the least affected by the addition of PBO (synergism ratios after cypermethrin was applied 1.9; after flumethrin 2.7) whereas N.R.F.S., the strain susceptible to SPs, was the most affected by synergism between PBO and SPs (synergism ratio after cypermethrin was applied 3.1; after flumethrin 8.9). We hypothesize that B. microplus lacks monooxygenases capable of conferring resistance to SPs because it and its recent ancestors were blood-feeders rather than herbivores.

Item Type:Article
Subjects:Veterinary medicine > Veterinary parasitology
Veterinary medicine > Diseases of special classes of animals > Cattle
Live Archive:06 Mar 2024 01:42
Last Modified:06 Mar 2024 01:42

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