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Multiple ciguatoxins in the flesh of fish

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Lewis, R. J. and Sellin, M. (1992) Multiple ciguatoxins in the flesh of fish. Toxicon, 30 (8). pp. 915-919. ISSN 0041-0101

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Article Link: https://doi.org/10.1016/0041-0101(92)90390-Q


Most cases of ciguatera (fish poisoning) result from consumption of the flesh of fishes contaminated with ciguatoxin(s); however, the relatively low toxicity of ciguateric fish flesh has hindered attempts to identify these ciguatoxin(s). Utilising high performance liquid chromatography, mass spectroscopy and mouse bioassay signs we have determined that ciguatoxin-1 (MH+m/z = 1112), ciguatoxin-2 and ciguatoxin-3 are the major ciguatoxins present in the flesh of ciguateric fish. Ciguatoxin-1, -2 and -3 were present in yields of 0.19, 0.09 and 0.02 μg/kg flesh, respectively, in Scomberomorus commersoni; 0.08, 0.09 and 0.07 μg/kg flesh, respectively, in Plectropomus spp. and; 0.67, 0.61 and 0.06 μg/kg flesh, respectively, in Pomadasys maculatus. Two minor toxins, which may be further oxidised analogues of ciguatoxin-1 and ciguatoxin-2, were also identified. The presence of multiple ciguatoxins in fish flesh has important consequences for the detection of ciguateric fish and may be a contributing factor to the observed variability in the symptoms of ciguatera.

Item Type:Article
Subjects:Science > Biology
Live Archive:16 Feb 2024 01:46
Last Modified:16 Feb 2024 01:46

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