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Characterization of moxidectin resistant Trichostrongylus colubriformis and Haemonchus contortus

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Le Jambre, L.F., Geoghegan, J. and Lyndal-Murphy, M. (2005) Characterization of moxidectin resistant Trichostrongylus colubriformis and Haemonchus contortus. Veterinary Parasitology, 128 (1-2). pp. 83-90. ISSN 0304-4017

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Article Link: https://doi.org/10.1016/j.vetpar.2004.10.019


The development of moxidectin resistance (MOX-R) in sheep parasitic gastrointestinal nematodes already carrying multiple resistances to other anthelmintic groups has made control of these strains very difficult. The anthelmintic resistance patterns of MOX-R strains of Trichostrongylus colubriformis and Haemonchus contortus were characterized to provide an insight into the remaining role of anthelmintics in the control of such strains. Homozygous MOX-R individuals of both genera were unaffected by moxidectin. For MOX-R heterozygotes a dose rate of 200 μg/kg abamectin (ABA) given orally removed 25% of H. contortus while 200 μg/kg MOX given orally achieved a 72% reduction. Doubling the dose rate of ABA improved the mean efficacy to 37%. Consequently, in H. contortus, the degree of dominance differs markedly between the two anthelmintics. A dose rate of 8mg/kg levamisole and 185 mg/kg napthalophos achieved >95% reduction in worm count of the MOX-R homozygous H. contortus but only 85 and 7%, respectively against the MOX-R homozygous T. colubriformis.

Item Type:Article
Keywords:Moxidectin; Abamectin; Napthalophos; Levamisole; Anthelmintic resistance; Trichostrongylus colubriformis; Haemonchus contortus; Sheep parasites; Goat parasites
Subjects:Veterinary medicine > Veterinary parasitology
Veterinary medicine > Diseases of special classes of animals > Sheep and goats
Live Archive:12 Feb 2024 21:52
Last Modified:12 Feb 2024 21:52

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