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Natural Hendra Virus Infection in Flying-Foxes - Tissue Tropism and Risk Factors

Goldspink, Lauren K. and Edson, Daniel W. and Vidgen, Miranda E. and Bingham, John and Field, Hume E. and Smith, Craig S. (2015) Natural Hendra Virus Infection in Flying-Foxes - Tissue Tropism and Risk Factors. PLoS ONE, 10 (6). e0128835.

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Article Link(s): http://dx.doi.org/10.1371/journal.pone.0128835

Abstract

Hendra virus (HeV) is a lethal zoonotic agent that emerged in 1994 in Australia. Pteropid bats (flying-foxes) are the natural reservoir. To date, HeV has spilled over from flying-foxes to horses on 51 known occasions, and from infected horses to close-contact humans on seven occasions. We undertook screening of archived bat tissues for HeV by reverse transcription quantitative polymerase chain reaction (RT-qPCR). Tissues were tested from 310 bats including 295 Pteropodiformes and 15 Vespertilioniformes. HeV was detected in 20 individual flying-foxes (6.4%) from various tissues including spleen, kidney, liver, lung, placenta and blood components. Detection was significantly higher in Pteropus Alecto and Pconspicillatus, identifying species as a risk factor for infection. Further, our findings indicate that HeV has a predilection for the spleen, suggesting this organ plays an important role in HeV infection. The lack of detections in the foetal tissues of HeV-positive females suggests that vertical transmission is not a regular mode of transmission in naturally infected flying-foxes, and that placental and foetal tissues are not a major source of infection for horses. A better understanding of HeV tissue tropism will strengthen management of the risk of spillover from flying-foxes to horses and ultimately humans.

Item Type:Article
Business groups:Biosecurity Queensland
Deposited On:09 Feb 2016 02:07
Last Modified:15 Feb 2016 04:51

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