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Do Human Extraintestinal Escherichia coli Infections Resistant to Expanded-Spectrum Cephalosporins Originate From Food-Producing Animals? A Systematic Review

Lazarus, B. and Paterson, D. L. and Mollinger, J. L. and Rogers, B. A. (2015) Do Human Extraintestinal Escherichia coli Infections Resistant to Expanded-Spectrum Cephalosporins Originate From Food-Producing Animals? A Systematic Review. Clinical Infectious Diseases, 60 (3). p. 439. ISSN 1058-4838

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Article Link(s): http://dx.doi.org/10.1093/cid/ciu785

Publisher URL: http://cid.oxfordjournals.org/content/60/3/439

Abstract

To find out whether food-producing animals (FPAs) are a source of extraintestinal expanded-spectrum cephalosporin-resistant Escherichia coli (ESCR-EC) infections in humans, Medline, Embase, and the Cochrane Database of Systematic Reviews were systematically reviewed. Thirty-four original, peer-reviewed publications were identified for inclusion. Six molecular epidemiology studies supported the transfer of resistance via whole bacterium transmission (WBT), which was best characterized among poultry in the Netherlands. Thirteen molecular epidemiology studies supported transmission of resistance via mobile genetic elements, which demonstrated greater diversity of geography and host FPA. Seventeen molecular epidemiology studies did not support WBT and two did not support mobile genetic element-mediated transmission. Four observational epidemiology studies were consistent with zoonotic transmission. Overall, there is evidence that a proportion of human extraintestinal ESCR-EC infections originate from FPAs. Poultry, in particular, is probably a source, but the quantitative and geographical extent of the problem is unclear and requires further investigation.

Item Type:Article
Business groups:Biosecurity Queensland
Keywords:E. coli ESBL poultry ST131 urinary tract zoonosis cephalosporin derivative bacterial transmission chicken meat enteropathogenic Escherichia coli enteropathogenic Escherichia coli infection Escherichia coli expanded spectrum cephalosporin resistant Escherichia coli expanded spectrum cephalosporin resistant Escherichia coli infection food industry food organism food producing animal human Klebsiella pneumoniae molecular epidemiology multilocus sequence typing Netherlands nonhuman priority journal pulsed field gel electrophoresis Review systematic review urinary tract infection whole bacterium transmission zoogeography
Subjects:Science > Microbiology > Microorganisms in the animal body
Veterinary medicine > Veterinary epidemiology. Epizootiology
Science > Microbiology
Science > Microbiology > Bacteria
Deposited On:18 Mar 2015 03:01
Last Modified:13 Aug 2015 02:34

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