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Synthesis of Silica Vesicles with Controlled Entrance Size for High Loading, Sustained Release, and Cellular Delivery of Therapeutical Proteins

Zhang, Jun and Karmakar, Surajit and Yu, Meihua and Mitter, Neena and Zou, Jin and Yu, Chengzhong (2014) Synthesis of Silica Vesicles with Controlled Entrance Size for High Loading, Sustained Release, and Cellular Delivery of Therapeutical Proteins. Small, 10 (24). pp. 5068-5076. ISSN 1613-6829

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Article Link(s): http://dx.doi.org/10.1002/smll.201401538

Abstract

A rationally designed two-step synthesis of silica vesicles is developed with the formation of vesicular structure in the first step and fine control over the entrance size by tuning the temperature in the second step. The silica vesicles have a uniform size of ≈50 nm with excellent cellular uptake performance. When the entrance size is equal to the wall thickness, silica vesicles after hydrophobic modification show the highest loading amount (563 mg/g) towards Ribonuclease A with a sustained release behavior. Consequently, the silica vesicles are excellent nano-carriers for cellular delivery applications of therapeutical biomolecules.

Item Type:Article
Business groups:Horticulture and Forestry Science
Keywords:silica vesicles entrance sizes cellular delivery sustained release therapeutic proteins
Subjects:Science > Botany
Plant culture
Deposited On:20 Jan 2015 02:24
Last Modified:20 Jan 2015 02:24

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