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Determining the proportion of heterozygotes using a normal mixture method of clustering: method applied to Pompe's disease in Brahman cattle.

Macbeth, G.M. and McPhee, C.P. and Reichmann, K.C. (1992) Determining the proportion of heterozygotes using a normal mixture method of clustering: method applied to Pompe's disease in Brahman cattle. In: International Trade in Breeds and Breeding Technology: Enhancing our Capability and Contribution, September 1992, Rockhampton.

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Publisher URL: http://www.aaabg.org/aaabg18/

Abstract

A mutant allele which lowers the activity of alpha-glucosidase (GLU%) acts as a recessive lethal in cattle. The distribution of 29,370 GLU% values from Brahman cattle was subject to analysis by the normal mixture method of clustering to determine presumptive distributions of heterozygotes and normal homozygotes. The heterozygote distribution was found to overlap the distribution of homozygous normals over the whole of its range of GLU% values, the proportion of heterozygotes being estimated as 12%. The probability of heterozygosity was calculated over a range of GLU % values.

Item Type:Conference or Workshop Item (Paper)
Additional Information:Reproduced with permission from Association for the Advancement of Animal Breeding and Genetics (AAABG).
Keywords:Brahman cattle; Pompe's disease; Determining heterozygotes.
Subjects:Animal culture > Breeding and breeds
Science > Biology > Genetics
Animal culture > Cattle
Deposited On:08 Jun 2004
Last Modified:13 Aug 2010 15:09

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