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Evidence of bat origin for Menangle virus, a zoonotic paramyxovirus first isolated from diseased pigs

Barr, J. A. and Smith, C. and Marsh, G. A. and Field, H. and Wang, L. F. (2012) Evidence of bat origin for Menangle virus, a zoonotic paramyxovirus first isolated from diseased pigs. Journal of General Virology, 93 (PART 12). pp. 2590-2594. ISSN 00221317

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Article Link(s): http://dx.doi.org/10.1099/vir.0.045385-0

Abstract

Menangle virus (MenPV) is a zoonotic paramyxovirus capable of causing disease in pigs and humans. It was first isolated in 1997 from stillborn piglets at a commercial piggery in New South Wales, Australia, where an outbreak of reproductive disease occurred. Neutralizing antibodies to MenPV were detected in various pteropid bat species in Australia and fruit bats were suspected to be the source of the virus responsible for the outbreak in pigs. However, previous attempts to isolate MenPV from various fruit bat species proved fruitless. Here, we report the isolation of MenPV from urine samples of the black flying fox, Pteropus alecto, using a combination of improved procedures and newly established bat cell lines. The nucleotide sequence of the bat isolate is 94% identical to the pig isolate. This finding provides strong evidence supporting the hypothesis that the MenPV outbreak in pigs originated from viruses in bats roosting near the piggery. © 2012 Printed in Great Britain.

Item Type:Article
Business groups:Biosecurity Queensland
Keywords:animal cell animal virus article bat cell line epidemic human human cell hypothesis menangle virus nonhuman nucleotide sequence Paramyxovirus paramyxovirus infection priority journal swine urinalysis virus isolation Animals Australia Chiroptera Epidemics Humans Molecular Sequence Data Phylogeography RNA, Viral Rubulavirus Rubulavirus Infections Species Specificity Sus scrofa Swine Diseases Zoonoses Paramyxoviridae Pteropus alecto Suidae
Subjects:Animal culture > Swine
Veterinary medicine > Communicable diseases of animals (General)
Deposited On:01 Nov 2013 06:54
Last Modified:01 Nov 2013 06:54

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