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Assessment of a low virulence Australian isolate of Anaplasma marginale for pathogenicity, immunogenicity and transmissibility by Boophilus microplus

Bock, R.E. and de Vos, A.J. and Kingston, T.G. and Carter, P.D. (2003) Assessment of a low virulence Australian isolate of Anaplasma marginale for pathogenicity, immunogenicity and transmissibility by Boophilus microplus. Veterinary Parasitology, 118 (1-2). pp. 121-131.

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Article Link(s): http://dx.doi.org/doi:10.1016/j.vetpar.2003.08.011

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Abstract

A 14-year-old cow (Dawn) born and kept in a Boophilus microplus-free region gave birth to a calf, which showed the presence of an Anaplasma marginale infection after splenectomy. The calf's grand dam was from a B. microplus infected area and we assume the infection originated via the transplacental route over two generations. An isolate, prepared from the calf, had similar or lower pathogenicity as Anaplasma centrale, and previously exposed steers were resistant to challenge by four A. marginale field isolates. Two attempts to transmit the isolate using B. microplus were unsuccessful. Our results indicate that Dawn A. marginale may be a useful vaccine in Australia and warrants larger scale validation of its safety and potency locally as well as of the protection it affords against African and New World isolates.

Item Type:Article
Corporate Creators:Biosecurity Queensland
Additional Information:© Elsevier
Keywords:Anaplasma marginale; Anaplasma centrale; Boophilus microplus; Vaccine; Tick transmission
Subjects:Veterinary medicine > Veterinary parasitology
Veterinary medicine > Other diseases and conditions
Deposited On:26 Feb 2004
Last Modified:24 Nov 2008 22:34

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