Turner, L.B. and Harrison, B.E. and Bunch, R.J. and Neto, L.R.P. and Li, Y.T. and Barendse, W. (2010) A genome-wide association study of tick burden and milk composition in cattle. Animal Production Science, 50 (4). pp. 235-245.
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Article Link(s): http://dx.doi.org/10.1071/an09135
Publisher URL: http://www.publish.csiro.au
To study the genetic basis of tick burden and milk production and their interrelationship, we collected a sample of 1961 cattle with multiple tick counts from northern Australia of which 973 had dairy production data in the Australian Dairy Herd Information Service database. We calculated heritabilities, genetic and phenotypic correlations for these traits and showed a negative relationship between tick counts and milk and milk component yield. Tests of polymorphisms of four genes associated with milk yield, ABCG2, DGAT1, GHR and PRLR, showed no statistically significant effect on tick burden but highly significant associations to milk component yield in these data and we confirmed separate effects for GHR and PRLR on bovine chromosome 20. To begin to identify some of the molecular genetic bases for these traits, we genotyped a sample of 189 of these cattle for 7397 single nucleotide polymorphisms in a genome-wide association study. Although the allele effects for adjusted milk fat and protein yield were highly correlated (r = 0.66), the correlations of allele effects of these milk component yields and tick burden were small (|r| <= 0.10). These results agree in general with the phenotypic correlations between tick counts and milk component yield and suggest that selection on markers for tick burden or milk component yield may have no undesirable effect on the other trait.
|Business groups:||Agri-Science, Crop and Food Science|
|Additional Information:||© CSIRO Publishing Open Access.|
|Keywords:||Quantitative trait locus; growth hormone receptor; tropical beef cattle; dairy cattle; Boophilus microplus; genetic parameters; Bos taurus; parasite resistance; missense mutation.|
|Subjects:||Science > Biology > Genetics > Quantitative genetics (esp. Quantitative Trait Loci (QTL) articles)|
Animal culture > Cattle > Dairying
Veterinary medicine > Veterinary parasitology
|Deposited On:||09 Sep 2010 01:29|
|Last Modified:||26 Oct 2011 04:48|
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