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Identification of two distinct bovine parainfluenza virus type 3 genotypes

Horwood, P.F. and Gravel, J.L. and Mahony, T.J. (2008) Identification of two distinct bovine parainfluenza virus type 3 genotypes. The Journal of general virology, 89 (Pt 7). pp. 1643-1648.

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Article Link(s): http://dx.doi.org/10.1099/vir.0.2008/000026-0

Publisher URL: http://www.sgmjournals.org/

Abstract

The partial gene sequencing of the matrix (M) protein from seven clinical isolates of bovine parainfluenza virus type 3 (BPIV-3), and the complete sequencing of a representative isolate (Q5592) was completed in this study. Nucleotide sequence analysis was initiated because of the failure of in-house BPIV-3 RT-PCR methods to yield expected products for four of the isolates. Phylogenetic reconstructions based on the nucleotide sequences for the M-protein and the entire genome, using all of the available BPIV-3 nucleotide sequences, demonstrated that there were two distinct BPIV-3 genotypes (BPIV-3a and BPIV-3b). These newly identified genotypes have implications for the development of BPIV-3 molecular detection methods and may also impact on BPIV-3 vaccine formulations.

Item Type:Article
Additional Information:© Society for General Microbiology.
Keywords:Matrix protein; Virus RNA; Animal; Cattle; Classification; DNA sequence; Genetics; Genotype; Human; Isolation and purification; Molecular genetics; Parainfluenza Virus 3; Phylogeny; RNA Virus infection; Sequence homology; Virology; Virus genome; Animals; Genome, Viral; Humans; Molecular Sequence Data; Parainfluenza Virus 3, Bovine; Respirovirus Infections; RNA, Viral; Sequence Analysis, DNA; Viral Matrix Proteins.
Subjects:Animal culture > Cattle
Science > Biology > Genetics
Veterinary medicine
Deposited On:13 Feb 2009 04:05
Last Modified:17 Feb 2009 06:49

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